Huettner Lab Publications

Huettner Lab Publications

2008

· Laezza F, Wilding TJ, Sequeira S, Craig AM, Huettner JE (2008) The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors. Neuropharmacology, in press.

· Wilding TJ, Fulling E, Zhou Y, Huettner JE (2008) Amino acid substitutions in the pore helix of GluR6 control inhibition by membrane fatty acids. Journal of General Physiology 32: 85-99.

2007

Laezza F, Wilding TJ, Sequeira S, Coussen F, Zhang XZ, Hill-Robinson R, Mulle C, Huettner JE, Craig AM (2007) KRIP6: A novel BTB/kelch protein regulating function of kainate receptors. Molecular and Cellular Neuroscience 34: 539-550. PMCID 1939939.

2006

Aton SJ, Huettner JE, Straume M, Herzog ED (2006) GABA and Gi/o differentially control circadian rhythms and synchrony in clock neurons. Proc Natl Acad Sci U S A. 103:19188-93.

Huettner JE, Lu A, Qu Y, Wu Y, Kim M, McDonald JW (2006) Gap Junctions and Connexon Hemichannels in Human Embryonic Stem Cells. Stem Cells. 24:1654-67.
Drenan RM, Doupnik CA, Jayaraman M, Buchwalter AL, Kaltenbronn KM, Huettner JE, Linder ME, Blumer KJ (2006) R7BP augments the function of RGS7/Gbeta 5 complexes by a plasma-membrane targeting mechanism. Journal of Biological Chemistry e-pub Jul 25.

2005

· Wilding TJ, Zhou Y, Huettner JE (2005) Q/R site editing controls kainate receptor inhibition by membrane fatty acids. Journal of Neuroscience 25:9470-9478.

Drenan RM, Doupnik CA, Boyle MP, Muglia LJ, Huettner JE, Linder ME, Blumer KJ (2005) Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family. Journal of Cell Biology 169:623-33.
Leevy WM, Gammon ST, Levchenko T, Daranciang DD, Murillo O, Torchilin V, Piwnica-Worms D, Huettner JE, and Gokel GW (2005) Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells. Organic and Biomolecular Chemistry 3:3544-3550.

2004

Leevy WM, Huettner JE, Pajewski R, Schlesinger PH, Gokel GW (2004) Synthetic ion channel activity documented by electrophysiological methods in living cells. Journal of the American Chemical Society 126:15747-53.
McDonald JW, Becker D, Huettner JE (2004) Spinal Cord Injury, in Handbook of Stem Cells. Vol. 1, Lanza R, ed., Academic Press, NY.

2003

· Huettner JE (2003) Kainate receptors and synaptic transmission. Progress in Neurobiology 70:387-407.

Huettner JE. (2003) Spine-tingling excitement from glutamate receptors. Science STKE. Nov 25;2003(210):pe53.

2002

Kerchner GA, Wilding TJ, Huettner JE and Zhuo M (2002) Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn. Journal of Neuroscience 22:8010-8107.
Huettner JE, Kerchner GA and Zhuo M (2002) Glutamate and the presynaptic control of spinal sensory transmission. The Neuroscientist 8:89-92.

2001

Kerchner GA, Wang G-D, Qui C-S, Huettner JE and Zhuo M (2001) Direct presynaptic regulation of GABA/glycine release by kainate receptors in the dorsal horn: an ionotropic mechanism. Neuron 32:477-488.
Wilding TJ and Huettner JE (2001) Functional Diversity and Developmental Changes in Neuronal Kainate Receptors. Journal of Physiology 532, 411-421.
Kerchner GA, Wilding TJ, Li P, Zhuo M and Huettner JE (2001) Presynaptic kainate receptors regulate spinal sensory transmission. Journal of Neuroscience 21:59-66.
Huettner JE (2001) Kainate receptors: knocking out plasticity. TINS 24, 365-366.

1999

· Finley MFA, Devata S and Huettner JE (1999) BMP-4 inhibits neural differentiation of murine embryonic stem cells. Journal of Neurobiology 40:271-287.

Gottlieb D.I. and Huettner J.E. (1999) An in vitro pathway from ES cells to neurons and Glia. Cells Tissues Organs, 165:165-172.
Li P, Kerchner GA, Sala C, Wei F, Huettner JE, Sheng M, Zhuo M (1999) AMPA receptor-PDZ interactions in facilitation of spinal sensory synapses. Nature Neuroscience 2:972-977.
Li P, Wilding TJ, Kim SJ, Calejesan AA, Huettner JE and Zhuo M. (1999) Kainate receptor-mediated sensory synaptic transmission in mammalian spinal cord. Nature, 397:161-164.

1998

Bain G., Yao M., Huettner J.E., Finley M.F.A., Gottlieb D.I. (1998) Neuron-like cells derived in culture from P19 embryonal carcinoma and embryonic stem cells. In "Culturing Nerve Cells, Second Edition" (Eds. Banker G and Goslin K), MIT Press, Cambridge, pp. 189-211.
Wilding T.J., Chai Y.-H. and Huettner J.E. (1998) Inhibition of rat neuronal kainate receptors by cis-unsaturated fatty acids. J. Physiol. 513:331-339.
Huettner J.E., Stack E. and Wilding T.J. (1998) Antagonism of Neuronal Kainate Receptors by Lanthanum and Gadolinium. Neuropharmacology, 37:1239-1247.
Segal M.M., Baughman R.W., Jones K.A., Huettner J.E. (1998) Mass cultures and microislands of neurons from postnatal rat brain. In: "Culturing Nerve Cells, 2nd Edition" (Eds. Banker G and Goslin K), MIT Press, Cambridge, pp. 309-338.

1997

Wilding T.J. and Huettner J.E. (1997) Activation and desensitization of hippocampal kainate receptors. J. Neurosci. 17:2713-2721.
Jones K.A., Wilding T.J., Huettner J.E., and Costa A.-M. (1997) Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36:853-863.

1996

Canzoniero L.M.T., Sensi S.L., Turetsky D.M., Finley M.F.A., Choi D.W., Huettner J.E. (1996) Glutamate receptor-mediated calcium entry in neurons derived from P19 embryonal carcinoma cells., Journal of Neuroscience Research 45:226-236.
Finley M.F.A., Kulkarni N., Huettner J.E. (1996) Synapse formation and establishment of neuronal polarity by P19 embryonic carcinoma cells and embryonic stem cells. Journal of Neuroscience 16:1056-65.
Guzikowski A.P., Cai S.X., Espitia S.A., Hawkinson J.E., Huettner J.E., Nogales D.F., Tran M., Woodward R.M., Weber E., and Keana J.F.W. (1996) Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: Structure-activity relationship at NMDA receptor glycine sites. J. Med. Chem. 39:4643-4653.
Wilding T.J., Huettner J.E. (1996) Antagonist pharmacology of kainate- and alpha-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA)-preferring receptors. Molecular Pharmacology 49:540-546.
Huettner J.E. (1996) Functional properties of kainate receptors. In "The Ionotropic Glutamate Receptors" (Eds. Monaghan DT and Wenthold R) Humana Press, inc., Totowa, N.J.; pp. 265-283.

1995

Bain G., Kitchens D., Yao M., Huettner J.E., and Gottlieb D.I. (1995) Embryonic stem cells express neuronal properties in vitro. Developmental Biology 168:342-357.
Wilding T.J., Huettner J.E. (1995) Differential antagonism of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-preferring and kainate-preferring receptors by 2,3-benzodiazepines. Molecular Pharmacology 47:582-587.
Woodward R.M., Huettner J.E., Guastella J., Keana J.F.W., and Weber E. (1995) Pharmacology of 5-chloro-7- trifluoromethyl-1,4-dihydro-2,3-quinoxalinedione: a novel systemically active ionotropic glutamate receptor antagonist. Journal of Pharmacology and Experamental Therapeutics 275:1209-18.

1994

Woodward R.M., Huettner J.E., Guastella J., Keana J.F.W., and Weber E. (1994) In vitro pharmacology of ACEA-1021 and ACEA-1031: Systemically active quinoxalinediones with high affinity and selectivity for N-methyl-D-aspartate receptor glycine sites. Molecular Pharmacology 47:568-581.

1993

Turetsky D.M., Huettner J.E., Gottlieb D.I., Goldberg M.P. and Choi D.W. (1993) Glutamate receptor-mediated currents and toxicity in embryonal carcinoma cells. Journal of Neurobiology 24:1157-1169.

1992

Swartz K.J., Koroshetz W.J., Rees A.H. and Huettner J.E. (1992) Competitive antagonism of glutamate receptor channels by substituted benzazepines in cultured cortical neurons. Molecular Pharmacology 41:1130-1141.

1991

Baughman R.W., Huettner J.E., Jones K.A. and Khan A.A. (1991) Cell culture of neocortex and basal forebrain from postnatal rats. In: "Culturing Nerve Cells" (Eds. Banker G and Goslin K), MIT Press, Cambridge, pp. 227-249.
Huettner J.E. (1991) Competitive antagonism of glycine at the NMDA receptor. Biochemical Pharmacology 40:9-16.

1990

Huettner J.E. (1990) Glutamate receptor channels in rat DRG neurons: Activation by kainate and quisqualate, and blockade of desensitization by Con A. Neuron 5:255-266.
Huettner J.E. (1990) Antagonists of NMDA-activated current in cortical neurons: competition with glycine and blockade of open channels. In: "Excitatory Amino Acids and Neuronal Plasticity" (Ed. Ben-Ari Y), Plenum, New York, pp. 35-43.

1989

Huettner J.E. (1989) Indole-2-carboxylic acid: A competitive antagonist of potentiation by glycine at the NMDA receptor. Science 243:1611-1613.

1988

Huettner J.E. and Bean B.P. (1988) Block of N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: Selective binding to open channels. PNAS, USA 85:1307-1311.
Huettner J.E. and Baughman R.W. (1988) The pharmacology of synapses formed by identified corticocollicular neurons in primary cultures of rat visual cortex. Journal of Neuroscience 8:160-175.

1986

· Huettner J.E. and Baughman R.W. (1986) Primary culture of identified neurons from the visual cortex of postnatal rats. Journal of Neuroscience 6:3044-3060.